home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-05 | 313.5 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000060| 00 01 45 43 00 00 94 0d | 00 00 30 36 00 00 00 01 |..EC....|..06....|
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|000000c0| 00 00 00 01 16 99 00 00 | b8 0c 00 00 31 33 00 00 |........|....13..|
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|00000310| e5 9c 02 00 74 0a 00 00 | 35 35 00 00 00 01 59 a7 |....t...|55....Y.|
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|00000380| a4 f9 02 00 95 0c 00 00 | 36 33 00 00 00 01 39 06 |........|63....9.|
|00000390| 03 00 ca 11 00 00 36 34 | 00 00 00 01 03 18 03 00 |......64|........|
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|000003d0| 00 00 00 01 89 55 03 00 | 33 09 00 00 36 39 00 00 |.....U..|3...69..|
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|000003f0| 29 6e 03 00 c8 08 00 00 | 37 31 00 00 00 01 f1 76 |)n......|71.....v|
|00000400| 03 00 5e 09 00 00 37 32 | 00 00 00 01 4f 80 03 00 |..^...72|....O...|
|00000410| bd 09 00 00 37 33 00 00 | 00 01 0c 8a 03 00 93 09 |....73..|........|
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|00000430| 37 35 00 00 00 01 17 9e | 03 00 b1 0b 00 00 37 36 |75......|......76|
|00000440| 00 00 00 01 c8 a9 03 00 | 87 0e 00 00 37 37 00 00 |........|....77..|
|00000450| 00 01 4f b8 03 00 5c 0f | 00 00 37 38 00 00 00 01 |..O...\.|..78....|
|00000460| ab c7 03 00 2c 0c 00 00 | 37 39 00 00 00 01 d7 d3 |....,...|79......|
|00000470| 03 00 22 11 00 00 38 30 | 00 00 00 01 f9 e4 03 00 |.."...80|........|
|00000480| 40 0b 00 00 38 31 00 00 | 00 01 39 f0 03 00 77 0a |@...81..|..9...w.|
|00000490| 00 00 38 32 00 00 00 01 | b0 fa 03 00 68 15 00 00 |..82....|....h...|
|000004a0| 38 33 00 00 00 01 18 10 | 04 00 44 0f 00 00 38 34 |83......|..D...84|
|000004b0| 00 00 00 01 5c 1f 04 00 | 53 0a 00 00 38 35 00 00 |....\...|S...85..|
|000004c0| 00 01 af 29 04 00 4b 0d | 00 00 38 36 00 00 00 01 |...)..K.|..86....|
|000004d0| fa 36 04 00 5b 0c 00 00 | 38 37 00 00 00 01 55 43 |.6..[...|87....UC|
|000004e0| 04 00 29 12 00 00 38 38 | 00 00 00 01 7e 55 04 00 |..)...88|....~U..|
|000004f0| 54 09 00 00 38 39 00 00 | 00 01 d2 5e 04 00 a2 0c |T...89..|...^....|
|00000500| 00 00 39 30 00 00 00 01 | 74 6b 04 00 53 10 00 00 |..90....|tk..S...|
|00000510| 39 31 00 00 00 01 c7 7b | 04 00 9c 09 00 00 39 32 |91.....{|......92|
|00000520| 00 00 00 01 63 85 04 00 | d5 0c 00 00 39 33 00 00 |....c...|....93..|
|00000530| 00 01 38 92 04 00 39 0a | 00 00 39 34 00 00 00 01 |..8...9.|..94....|
|00000540| 71 9c 04 00 03 09 00 00 | 39 35 00 00 00 01 74 a5 |q.......|95....t.|
|00000550| 04 00 72 0b 00 00 39 36 | 00 00 00 01 e6 b0 04 00 |..r...96|........|
|00000560| f7 0a 00 00 39 37 00 00 | 00 01 dd bb 04 00 e2 0e |....97..|........|
|00000570| 00 00 39 38 00 00 00 01 | bf ca 04 00 21 09 00 00 |..98....|....!...|
|00000580| 39 39 00 00 00 01 e0 d3 | 04 00 11 12 00 00 00 00 |99......|........|
|00000590| 00 00 00 00 f1 e5 04 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 32 38 30 30 7d |que_ID{Y|RB02800}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 54 72 65 61 74 6d 65 |..$Title|{Treatme|
|000005c0| 6e 74 20 6f 66 20 53 65 | 76 65 72 65 20 50 72 65 |nt of Se|vere Pre|
|000005d0| 6d 65 6e 73 74 72 75 61 | 6c 20 53 79 6e 64 72 6f |menstrua|l Syndro|
|000005e0| 6d 65 20 57 69 74 68 20 | 4f 65 73 74 72 61 64 69 |me With |Oestradi|
|000005f0| 6f 6c 20 50 61 74 63 68 | 65 73 20 61 6e 64 0d 0a |ol Patch|es and..|
|00000600| 43 79 63 6c 69 63 61 6c | 20 4f 72 61 6c 20 4e 6f |Cyclical| Oral No|
|00000610| 72 65 74 68 69 73 74 65 | 72 6f 6e 65 7d 0d 0a 24 |rethiste|rone}..$|
|00000620| 41 75 74 68 6f 72 7b 0d | 0a 57 61 74 73 6f 6e 2c |Author{.|.Watson,|
|00000630| 20 4e 52 0d 0a 53 74 75 | 66 66 2c 20 4a 57 57 0d | NR..Stu|ff, JWW.|
|00000640| 0a 53 61 76 76 61 73 2c | 20 4d 0d 0a 47 61 72 6e |.Savvas,| M..Garn|
|00000650| 65 74 74 2c 20 54 0d 0a | 42 61 62 65 72 2c 20 52 |ett, T..|Baber, R|
|00000660| 4a 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |J}..$Aff|iliation|
|00000670| 7b 44 75 6c 77 69 63 68 | 20 48 6f 73 70 2c 20 4c |{Dulwich| Hosp, L|
|00000680| 6f 6e 64 6f 6e 7d 0d 0a | 24 4a 6f 75 72 6e 61 6c |ondon}..|$Journal|
|00000690| 7b 4c 61 6e 63 65 74 7d | 0d 0a 24 56 6f 6c 75 6d |{Lancet}|..$Volum|
|000006a0| 65 7b 32 7d 0d 0a 24 50 | 61 67 65 7b 37 33 30 2d |e{2}..$P|age{730-|
|000006b0| 37 33 32 7d 0d 0a 24 44 | 61 74 65 7b 31 39 38 39 |732}..$D|ate{1989|
|000006c0| 7d 0d 0a 24 59 42 56 6f | 6c 7b 31 39 39 31 20 59 |}..$YBVo|l{1991 Y|
|000006d0| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 4f 62 73 74 |ear Book| of Obst|
|000006e0| 65 74 72 69 63 73 20 61 | 6e 64 20 47 79 6e 65 63 |etrics a|nd Gynec|
|000006f0| 6f 6c 6f 67 79 7d 0d 0a | 24 43 68 61 70 74 65 72 |ology}..|$Chapter|
|00000700| 7b 32 31 2d 35 7d 0d 0a | 24 59 42 45 64 69 74 6f |{21-5}..|$YBEdito|
|00000710| 72 7b 44 72 73 2e 20 4d | 69 73 68 65 6c 6c 2c 20 |r{Drs. M|ishell, |
|00000720| 4b 69 72 73 63 68 62 61 | 75 6d 2c 20 61 6e 64 20 |Kirschba|um, and |
|00000730| 4d 6f 72 72 6f 77 7d 0d | 0a 24 54 61 62 6c 65 7b |Morrow}.|.$Table{|
|00000740| 7d 0d 0a 24 43 6f 6d 6d | 65 6e 74 61 74 6f 72 7b |}..$Comm|entator{|
|00000750| 44 2e 52 2e 20 4d 69 73 | 68 65 6c 6c 2c 20 4a 72 |D.R. Mis|hell, Jr|
|00000760| 2e 2c 20 4d 2e 44 2e 7d | 0d 0a 0d 0a 43 6f 70 79 |., M.D.}|....Copy|
|00000770| 72 69 67 68 74 20 28 43 | 29 20 59 65 61 72 20 42 |right (C|) Year B|
|00000780| 6f 6f 6b 20 4d 65 64 69 | 63 61 6c 20 50 75 62 6c |ook Medi|cal Publ|
|00000790| 69 73 68 65 72 73 2c 20 | 49 6e 63 2e 20 31 39 39 |ishers, |Inc. 199|
|000007a0| 31 0d 0a 0d 0a 31 39 39 | 31 20 59 65 61 72 20 42 |1....199|1 Year B|
|000007b0| 6f 6f 6b 20 6f 66 20 4f | 62 73 74 65 74 72 69 63 |ook of O|bstetric|
|000007c0| 73 20 61 6e 64 20 47 79 | 6e 65 63 6f 6c 6f 67 79 |s and Gy|necology|
|000007d0| 0d 0a 0d 0a 47 79 6e 65 | 63 6f 6c 6f 67 79 0d 0a |....Gyne|cology..|
|000007e0| 0d 0a 43 68 61 70 74 65 | 72 20 32 31 20 2d 2d 20 |..Chapte|r 21 -- |
|000007f0| 53 65 78 75 61 6c 69 74 | 79 20 61 6e 64 20 50 72 |Sexualit|y and Pr|
|00000800| 65 6d 65 6e 73 74 72 75 | 61 6c 20 53 79 6e 64 72 |emenstru|al Syndr|
|00000810| 6f 6d 65 0d 0a 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d |ome....-|--------|
|00000820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000830| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000860| 2d 2d 2d 2d 2d 0d 0a 54 | 72 65 61 74 6d 65 6e 74 |-----..T|reatment|
|00000870| 20 6f 66 20 53 65 76 65 | 72 65 20 50 72 65 6d 65 | of Seve|re Preme|
|00000880| 6e 73 74 72 75 61 6c 20 | 53 79 6e 64 72 6f 6d 65 |nstrual |Syndrome|
|00000890| 20 57 69 74 68 20 4f 65 | 73 74 72 61 64 69 6f 6c | With Oe|stradiol|
|000008a0| 20 50 61 74 63 68 65 73 | 20 61 6e 64 20 43 79 63 | Patches| and Cyc|
|000008b0| 6c 69 63 61 6c 0d 0a 4f | 72 61 6c 20 4e 6f 72 65 |lical..O|ral Nore|
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|000008d0| 74 73 6f 6e 20 4e 52 3b | 20 53 74 75 66 66 20 4a |tson NR;| Stuff J|
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|000008f0| 72 6e 65 74 74 20 54 3b | 20 42 61 62 65 72 20 52 |rnett T;| Baber R|
|00000900| 4a 0d 0a 28 44 75 6c 77 | 69 63 68 20 48 6f 73 70 |J..(Dulw|ich Hosp|
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|00000920| 74 20 32 3a 37 33 30 2d | 37 33 32 2c 20 31 39 38 |t 2:730-|732, 198|
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|00000950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00000a10| 20 6d 65 74 68 6f 64 20 | 6f 66 20 70 65 72 63 75 | method |of percu|
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|00000a90| 61 74 6d 65 6e 74 2e 20 | 20 41 20 70 6c 61 63 65 |atment. | A place|
|00000aa0| 62 6f 2d 63 6f 6e 74 72 | 6f 6c 6c 65 64 2c 20 63 |bo-contr|olled, c|
|00000ab0| 72 6f 73 73 6f 76 65 72 | 20 73 74 75 64 79 20 6f |rossover| study o|
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|00000ad0| 63 68 65 73 20 77 61 73 | 20 63 61 72 72 69 65 64 |ches was| carried|
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|00000af0| 6e 20 77 69 74 68 20 70 | 72 65 6d 65 6e 73 74 72 |n with p|remenstr|
|00000b00| 75 61 6c 20 73 79 6d 70 | 74 6f 6d 73 2e 0d 0a 45 |ual symp|toms...E|
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|00000b20| 20 20 61 63 74 69 76 65 | 20 70 61 74 63 68 65 73 | active| patches|
|00000b30| 20 28 32 20 78 20 31 30 | 30 20 6d 75 5f 67 29 20 | (2 x 10|0 mu_g) |
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|00000b70| 72 6f 6e 65 20 6f 6e 20 | 63 79 63 6c 65 20 64 61 |rone on |cycle da|
|00000b80| 79 73 20 31 39 2d 32 36 | 2e 20 20 45 61 63 68 20 |ys 19-26|. Each |
|00000b90| 74 72 65 61 74 6d 65 6e | 74 20 77 61 73 20 75 73 |treatmen|t was us|
|00000ba0| 65 64 20 66 6f 72 20 33 | 0d 0a 6d 6f 6e 74 68 73 |ed for 3|..months|
|00000bb0| 2e 0d 0a 20 20 20 20 20 | 46 6f 75 72 20 70 61 74 |... |Four pat|
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|00000bf0| 73 20 6f 6e 20 74 68 65 | 20 4d 6f 6f 73 0d 0a 6d |s on the| Moos..m|
|00000c00| 65 6e 73 74 72 75 61 6c | 20 64 69 73 74 72 65 73 |enstrual| distres|
|00000c10| 73 20 71 75 65 73 74 69 | 6f 6e 6e 61 69 72 65 20 |s questi|onnaire |
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|00000c30| 72 75 61 6c 20 64 69 73 | 74 72 65 73 73 20 71 75 |rual dis|tress qu|
|00000c40| 65 73 74 69 6f 6e 6e 61 | 69 72 65 0d 0a 69 6d 70 |estionna|ire..imp|
|00000c50| 72 6f 76 65 64 20 69 6e | 20 62 6f 74 68 20 67 72 |roved in| both gr|
|00000c60| 6f 75 70 73 20 69 6e 69 | 74 69 61 6c 6c 79 2e 20 |oups ini|tially. |
|00000c70| 20 41 66 74 65 72 20 33 | 20 6d 6f 6e 74 68 73 2c | After 3| months,|
|00000c80| 20 68 6f 77 65 76 65 72 | 2c 20 77 6f 6d 65 6e 20 | however|, women |
|00000c90| 63 68 61 6e 67 69 6e 67 | 20 74 6f 0d 0a 61 63 74 |changing| to..act|
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|00000cf0| 73 65 6e 69 6e 67 20 73 | 63 6f 72 65 73 2e 20 20 |sening s|cores. |
|00000d00| 4e 6f 20 73 69 67 6e 69 | 66 69 63 61 6e 74 20 62 |No signi|ficant b|
|00000d10| 6c 6f 6f 64 20 70 72 65 | 73 73 75 72 65 20 6f 72 |lood pre|ssure or|
|00000d20| 20 77 65 69 67 68 74 20 | 63 68 61 6e 67 65 73 20 | weight |changes |
|00000d30| 77 65 72 65 20 6e 6f 74 | 65 64 2e 0d 0a 20 20 20 |were not|ed... |
|00000d40| 20 20 54 72 61 6e 73 64 | 65 72 6d 61 6c 20 65 73 | Transd|ermal es|
|00000d50| 74 72 61 64 69 6f 6c 20 | 69 73 20 61 6e 20 65 66 |tradiol |is an ef|
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|00001b30| 20 20 20 20 50 79 72 69 | 64 6f 78 69 6e 65 20 61 | Pyri|doxine a|
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|00001ba0| 72 65 6d 65 6e 73 74 72 | 75 61 6c 20 70 65 72 69 |remenstr|ual peri|
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|00001be0| 73 79 6d 70 74 6f 6d 73 | 20 69 6e 20 77 6f 6d 65 |symptoms| in wome|
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|00001ca0| 65 61 72 6c 69 65 72 20 | 74 72 69 61 6c 73 20 72 |earlier |trials r|
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|00001d20| 20 65 66 66 65 63 74 20 | 6f 66 20 74 68 65 20 61 | effect |of the a|
|00001d30| 67 65 6e 74 2e 0d 0a 54 | 68 65 20 72 65 73 75 6c |gent...T|he resul|
|00001d40| 74 73 20 6f 66 20 74 68 | 69 73 20 73 74 75 64 79 |ts of th|is study|
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|00001d70| 65 66 66 65 63 74 20 6f | 66 20 74 68 65 0d 0a 70 |effect o|f the..p|
|00001d80| 6c 61 63 65 62 6f 2c 20 | 61 6c 73 6f 20 66 6f 75 |lacebo, |also fou|
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|00001da0| 20 70 79 72 69 64 6f 78 | 69 6e 65 20 61 20 64 61 | pyridox|ine a da|
|00001db0| 79 20 72 65 73 75 6c 74 | 65 64 20 69 6e 20 61 20 |y result|ed in a |
|00001dc0| 73 69 67 6e 69 66 69 63 | 61 6e 74 6c 79 0d 0a 67 |signific|antly..g|
|00001dd0| 72 65 61 74 65 72 20 72 | 65 64 75 63 74 69 6f 6e |reater r|eduction|
|00001de0| 20 69 6e 20 74 68 65 20 | 69 6e 63 69 64 65 6e 63 | in the |incidenc|
|00001df0| 65 20 6f 66 20 64 65 70 | 72 65 73 73 69 6f 6e 2c |e of dep|ression,|
|00001e00| 20 69 72 72 69 74 61 62 | 69 6c 69 74 79 2c 20 61 | irritab|ility, a|
|00001e10| 6e 64 20 74 69 72 65 64 | 6e 65 73 73 2c 0d 0a 74 |nd tired|ness,..t|
|00001e20| 68 65 20 6d 61 6a 6f 72 | 20 63 6f 6d 70 6c 61 69 |he major| complai|
|00001e30| 6e 74 73 20 6f 66 20 77 | 6f 6d 65 6e 20 77 69 74 |nts of w|omen wit|
|00001e40| 68 20 50 4d 53 2e 20 20 | 50 79 72 69 64 6f 78 69 |h PMS. |Pyridoxi|
|00001e50| 6e 65 20 64 69 64 20 6e | 6f 74 20 72 65 64 75 63 |ne did n|ot reduc|
|00001e60| 65 20 74 68 65 0d 0a 69 | 6e 63 69 64 65 6e 63 65 |e the..i|ncidence|
|00001e70| 20 6f 66 20 73 6f 6d 61 | 74 69 63 20 65 66 66 65 | of soma|tic effe|
|00001e80| 63 74 73 20 28 65 2e 67 | 2e 2c 20 65 64 65 6d 61 |cts (e.g|., edema|
|00001e90| 20 61 6e 64 20 68 65 61 | 64 61 63 68 65 29 20 6f | and hea|dache) o|
|00001ea0| 72 20 6d 65 6e 73 74 72 | 75 61 6c 0d 0a 63 6f 6d |r menstr|ual..com|
|00001eb0| 70 6c 61 69 6e 74 73 2c | 20 65 2e 67 2e 2c 20 62 |plaints,| e.g., b|
|00001ec0| 61 63 6b 61 63 68 65 2e | 20 20 41 6c 74 68 6f 75 |ackache.| Althou|
|00001ed0| 67 68 20 68 69 67 68 65 | 72 20 64 6f 73 65 73 20 |gh highe|r doses |
|00001ee0| 6f 66 20 70 79 72 69 64 | 6f 78 69 6e 65 20 68 61 |of pyrid|oxine ha|
|00001ef0| 76 65 20 62 65 65 6e 0d | 0a 72 65 70 6f 72 74 65 |ve been.|.reporte|
|00001f00| 64 20 74 6f 20 63 61 75 | 73 65 20 61 64 76 65 72 |d to cau|se adver|
|00001f10| 73 65 20 6e 65 75 72 6f | 6c 6f 67 69 63 20 63 68 |se neuro|logic ch|
|00001f20| 61 6e 67 65 73 20 69 6e | 20 73 6f 6d 65 20 77 6f |anges in| some wo|
|00001f30| 6d 65 6e 2c 20 69 6e 20 | 74 68 69 73 20 73 74 75 |men, in |this stu|
|00001f40| 64 79 20 6e 6f 0d 0a 77 | 6f 6d 65 6e 20 63 6f 6d |dy no..w|omen com|
|00001f50| 70 6c 61 69 6e 65 64 20 | 6f 66 20 73 69 64 65 20 |plained |of side |
|00001f60| 65 66 66 65 63 74 73 2c | 20 70 6f 73 73 69 62 6c |effects,| possibl|
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|00001f80| 20 6c 6f 77 20 64 6f 73 | 61 67 65 20 75 73 65 64 | low dos|age used|
|00001f90| 2e 0d 0a 43 6c 69 6e 69 | 63 69 61 6e 73 20 6d 61 |...Clini|cians ma|
|00001fa0| 79 20 77 69 73 68 20 74 | 6f 20 75 73 65 20 74 68 |y wish t|o use th|
|00001fb0| 69 73 20 72 65 6c 61 74 | 69 76 65 6c 79 20 69 6e |is relat|ively in|
|00001fc0| 6e 6f 63 75 6f 75 73 20 | 61 67 65 6e 74 20 66 6f |nocuous |agent fo|
|00001fd0| 72 20 74 68 65 20 74 72 | 65 61 74 6d 65 6e 74 0d |r the tr|eatment.|
|00001fe0| 0a 6f 66 20 74 68 65 20 | 65 6d 6f 74 69 6f 6e 61 |.of the |emotiona|
|00001ff0| 6c 20 63 6f 6d 70 6f 6e | 65 6e 74 20 6f 66 20 50 |l compon|ent of P|
|00002000| 4d 53 2e 2d 2d 44 2e 52 | 2e 20 4d 69 73 68 65 6c |MS.--D.R|. Mishel|
|00002010| 6c 2c 20 4a 72 2e 2c 20 | 4d 2e 44 2e 0d 0a 24 55 |l, Jr., |M.D...$U|
|00002020| 6e 69 71 75 65 5f 49 44 | 7b 59 52 42 30 32 38 30 |nique_ID|{YRB0280|
|00002030| 32 7d 0d 0a 24 54 69 74 | 6c 65 7b 4e 61 70 72 6f |2}..$Tit|le{Napro|
|00002040| 78 65 6e 20 53 6f 64 69 | 75 6d 20 69 6e 20 74 68 |xen Sodi|um in th|
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|00002060| 72 65 6d 65 6e 73 74 72 | 75 61 6c 20 53 79 6d 70 |remenstr|ual Symp|
|00002070| 74 6f 6d 73 3a 20 20 41 | 0d 0a 50 6c 61 63 65 62 |toms: A|..Placeb|
|00002080| 6f 2d 43 6f 6e 74 72 6f | 6c 6c 65 64 20 53 74 75 |o-Contro|lled Stu|
|00002090| 64 79 7d 0d 0a 24 41 75 | 74 68 6f 72 7b 0d 0a 46 |dy}..$Au|thor{..F|
|000020a0| 61 63 63 68 69 6e 65 74 | 74 69 2c 20 46 0d 0a 46 |acchinet|ti, F..F|
|000020b0| 69 6f 72 6f 6e 69 2c 20 | 4c 0d 0a 53 61 6e 63 65 |ioroni, |L..Sance|
|000020c0| 73 2c 20 47 0d 0a 52 6f | 6d 61 6e 6f 2c 20 47 0d |s, G..Ro|mano, G.|
|000020d0| 0a 4e 61 70 70 69 2c 20 | 47 0d 0a 47 65 6e 61 7a |.Nappi, |G..Genaz|
|000020e0| 7a 61 6e 69 2c 20 41 52 | 7d 0d 0a 24 41 66 66 69 |zani, AR|}..$Affi|
|000020f0| 6c 69 61 74 69 6f 6e 7b | 55 6e 69 76 20 6f 66 20 |liation{|Univ of |
|00002100| 4d 6f 64 65 6e 61 3b 20 | 55 6e 69 76 20 6f 66 20 |Modena; |Univ of |
|00002110| 50 61 76 69 61 2c 20 49 | 74 61 6c 79 7d 0d 0a 24 |Pavia, I|taly}..$|
|00002120| 4a 6f 75 72 6e 61 6c 7b | 47 79 6e 65 63 6f 6c 20 |Journal{|Gynecol |
|00002130| 4f 62 73 74 65 74 20 49 | 6e 76 65 73 74 7d 0d 0a |Obstet I|nvest}..|
|00002140| 24 56 6f 6c 75 6d 65 7b | 32 38 7d 0d 0a 24 50 61 |$Volume{|28}..$Pa|
|00002150| 67 65 7b 32 30 35 2d 32 | 30 38 7d 0d 0a 24 44 61 |ge{205-2|08}..$Da|
|00002160| 74 65 7b 31 39 38 39 7d | 0d 0a 24 59 42 56 6f 6c |te{1989}|..$YBVol|
|00002170| 7b 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |{1991 Ye|ar Book |
|00002180| 6f 66 20 4f 62 73 74 65 | 74 72 69 63 73 20 61 6e |of Obste|trics an|
|00002190| 64 20 47 79 6e 65 63 6f | 6c 6f 67 79 7d 0d 0a 24 |d Gyneco|logy}..$|
|000021a0| 43 68 61 70 74 65 72 7b | 32 31 2d 37 7d 0d 0a 24 |Chapter{|21-7}..$|
|000021b0| 59 42 45 64 69 74 6f 72 | 7b 44 72 73 2e 20 4d 69 |YBEditor|{Drs. Mi|
|000021c0| 73 68 65 6c 6c 2c 20 4b | 69 72 73 63 68 62 61 75 |shell, K|irschbau|
|000021d0| 6d 2c 20 61 6e 64 20 4d | 6f 72 72 6f 77 7d 0d 0a |m, and M|orrow}..|
|000021e0| 24 54 61 62 6c 65 7b 7d | 0d 0a 24 43 6f 6d 6d 65 |$Table{}|..$Comme|
|000021f0| 6e 74 61 74 6f 72 7b 44 | 2e 52 2e 20 4d 69 73 68 |ntator{D|.R. Mish|
|00002200| 65 6c 6c 2c 20 4a 72 2e | 2c 20 4d 2e 44 2e 7d 0d |ell, Jr.|, M.D.}.|
|00002210| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 43 29 |...Copyr|ight (C)|
|00002220| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00002230| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00002240| 6e 63 2e 20 31 39 39 31 | 0d 0a 0d 0a 31 39 39 31 |nc. 1991|....1991|
|00002250| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 4f 62 | Year Bo|ok of Ob|
|00002260| 73 74 65 74 72 69 63 73 | 20 61 6e 64 20 47 79 6e |stetrics| and Gyn|
|00002270| 65 63 6f 6c 6f 67 79 0d | 0a 0d 0a 47 79 6e 65 63 |ecology.|...Gynec|
|00002280| 6f 6c 6f 67 79 0d 0a 0d | 0a 43 68 61 70 74 65 72 |ology...|.Chapter|
|00002290| 20 32 31 20 2d 2d 20 53 | 65 78 75 61 6c 69 74 79 | 21 -- S|exuality|
|000022a0| 20 61 6e 64 20 50 72 65 | 6d 65 6e 73 74 72 75 61 | and Pre|menstrua|
|000022b0| 6c 20 53 79 6e 64 72 6f | 6d 65 0d 0a 0d 0a 2d 2d |l Syndro|me....--|
|000022c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002300| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 4e 61 |--------|----..Na|
|00002310| 70 72 6f 78 65 6e 20 53 | 6f 64 69 75 6d 20 69 6e |proxen S|odium in|
|00002320| 20 74 68 65 20 54 72 65 | 61 74 6d 65 6e 74 20 6f | the Tre|atment o|
|00002330| 66 20 50 72 65 6d 65 6e | 73 74 72 75 61 6c 20 53 |f Premen|strual S|
|00002340| 79 6d 70 74 6f 6d 73 3a | 20 20 41 0d 0a 50 6c 61 |ymptoms:| A..Pla|
|00002350| 63 65 62 6f 2d 43 6f 6e | 74 72 6f 6c 6c 65 64 20 |cebo-Con|trolled |
|00002360| 53 74 75 64 79 0d 0a 0d | 0a 46 61 63 63 68 69 6e |Study...|.Facchin|
|00002370| 65 74 74 69 20 46 3b 20 | 46 69 6f 72 6f 6e 69 20 |etti F; |Fioroni |
|00002380| 4c 3b 20 53 61 6e 63 65 | 73 20 47 3b 20 52 6f 6d |L; Sance|s G; Rom|
|00002390| 61 6e 6f 20 47 3b 20 4e | 61 70 70 69 20 47 3b 20 |ano G; N|appi G; |
|000023a0| 47 65 6e 61 7a 7a 61 6e | 69 20 41 52 0d 0a 28 55 |Genazzan|i AR..(U|
|000023b0| 6e 69 76 20 6f 66 20 4d | 6f 64 65 6e 61 3b 20 55 |niv of M|odena; U|
|000023c0| 6e 69 76 20 6f 66 20 50 | 61 76 69 61 2c 20 49 74 |niv of P|avia, It|
|000023d0| 61 6c 79 29 0d 0a 47 79 | 6e 65 63 6f 6c 20 4f 62 |aly)..Gy|necol Ob|
|000023e0| 73 74 65 74 20 49 6e 76 | 65 73 74 20 32 38 3a 32 |stet Inv|est 28:2|
|000023f0| 30 35 2d 32 30 38 2c 20 | 31 39 38 39 0d 0a 2d 2d |05-208, |1989..--|
|00002400| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002410| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002420| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002430| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002440| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00002450| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00002460| 20 54 68 65 20 70 72 6f | 73 74 61 67 6c 61 6e 64 | The pro|stagland|
|00002470| 69 6e 20 73 79 73 74 65 | 6d 20 69 73 20 62 65 6c |in syste|m is bel|
|00002480| 69 65 76 65 64 20 74 6f | 20 68 61 76 65 20 61 20 |ieved to| have a |
|00002490| 72 6f 6c 65 20 69 6e 20 | 74 68 65 20 63 61 75 73 |role in |the caus|
|000024a0| 65 20 6f 66 0d 0a 70 72 | 65 6d 65 6e 73 74 72 75 |e of..pr|emenstru|
|000024b0| 61 6c 20 73 79 6e 64 72 | 6f 6d 65 20 28 50 4d 53 |al syndr|ome (PMS|
|000024c0| 29 2e 20 20 4d 61 6e 79 | 20 61 75 74 68 6f 72 73 |). Many| authors|
|000024d0| 20 74 68 69 6e 6b 20 74 | 68 61 74 20 70 72 6f 73 | think t|hat pros|
|000024e0| 74 61 67 6c 61 6e 64 69 | 6e 73 20 61 72 65 0d 0a |taglandi|ns are..|
|000024f0| 69 6e 76 6f 6c 76 65 64 | 20 69 6e 20 62 6f 74 68 |involved| in both|
|00002500| 20 63 65 6e 74 72 61 6c | 20 61 6e 64 20 70 65 72 | central| and per|
|00002510| 69 70 68 65 72 61 6c 20 | 73 79 6d 70 74 6f 6d 73 |ipheral |symptoms|
|00002520| 2e 20 20 54 6f 20 74 65 | 73 74 20 74 68 69 73 20 |. To te|st this |
|00002530| 68 79 70 6f 74 68 65 73 | 69 73 20 74 68 65 0d 0a |hypothes|is the..|
|00002540| 65 66 66 65 63 74 20 6f | 66 20 6e 61 70 72 6f 78 |effect o|f naprox|
|00002550| 65 6e 20 73 6f 64 69 75 | 6d 20 6f 6e 20 50 4d 53 |en sodiu|m on PMS|
|00002560| 20 73 79 6d 70 74 6f 6d | 73 20 77 61 73 20 61 73 | symptom|s was as|
|00002570| 73 65 73 73 65 64 20 69 | 6e 20 61 20 64 6f 75 62 |sessed i|n a doub|
|00002580| 6c 65 2d 62 6c 69 6e 64 | 2c 0d 0a 70 6c 61 63 65 |le-blind|,..place|
|00002590| 62 6f 2d 63 6f 6e 74 72 | 6f 6c 6c 65 64 20 74 72 |bo-contr|olled tr|
|000025a0| 69 61 6c 20 69 6e 20 33 | 34 20 77 6f 6d 65 6e 20 |ial in 3|4 women |
|000025b0| 61 66 66 65 63 74 65 64 | 20 62 79 20 50 4d 53 20 |affected| by PMS |
|000025c0| 66 6f 72 20 32 2d 37 20 | 79 65 61 72 73 20 77 68 |for 2-7 |years wh|
|000025d0| 6f 73 65 0d 0a 73 79 6d | 70 74 6f 6d 73 20 68 61 |ose..sym|ptoms ha|
|000025e0| 64 20 72 65 63 65 6e 74 | 6c 79 20 77 6f 72 73 65 |d recent|ly worse|
|000025f0| 6e 65 64 2e 20 20 41 66 | 74 65 72 20 61 20 32 2d |ned. Af|ter a 2-|
|00002600| 6d 6f 6e 74 68 20 72 75 | 6e 2d 69 6e 20 70 65 72 |month ru|n-in per|
|00002610| 69 6f 64 2c 20 74 68 65 | 20 77 6f 6d 65 6e 20 77 |iod, the| women w|
|00002620| 65 72 65 0d 0a 61 73 73 | 69 67 6e 65 64 20 74 6f |ere..ass|igned to|
|00002630| 20 70 6c 61 63 65 62 6f | 20 6f 72 20 64 72 75 67 | placebo| or drug|
|00002640| 20 74 72 65 61 74 6d 65 | 6e 74 20 66 6f 72 20 74 | treatme|nt for t|
|00002650| 68 65 69 72 20 66 69 72 | 73 74 20 33 20 63 79 63 |heir fir|st 3 cyc|
|00002660| 6c 65 73 2e 20 20 49 6e | 20 74 68 65 20 6e 65 78 |les. In| the nex|
|00002670| 74 20 33 0d 0a 63 79 63 | 6c 65 73 2c 20 61 6c 6c |t 3..cyc|les, all|
|00002680| 20 77 6f 6d 65 6e 20 77 | 65 72 65 20 67 69 76 65 | women w|ere give|
|00002690| 6e 20 74 68 65 20 61 63 | 74 69 76 65 20 64 72 75 |n the ac|tive dru|
|000026a0| 67 2e 20 20 4e 61 70 72 | 6f 78 65 6e 20 73 6f 64 |g. Napr|oxen sod|
|000026b0| 69 75 6d 2c 20 35 35 30 | 2d 6d 67 0d 0a 74 61 62 |ium, 550|-mg..tab|
|000026c0| 6c 65 74 73 2c 20 6f 72 | 20 70 6c 61 63 65 62 6f |lets, or| placebo|
|000026d0| 20 77 61 73 20 67 69 76 | 65 6e 20 65 76 65 72 79 | was giv|en every|
|000026e0| 20 31 32 20 68 6f 75 72 | 73 20 62 65 67 69 6e 6e | 12 hour|s beginn|
|000026f0| 69 6e 67 20 37 20 64 61 | 79 73 20 62 65 66 6f 72 |ing 7 da|ys befor|
|00002700| 65 20 74 68 65 0d 0a 65 | 78 70 65 63 74 65 64 20 |e the..e|xpected |
|00002710| 6d 65 6e 73 65 73 20 75 | 6e 74 69 6c 20 74 68 65 |menses u|ntil the|
|00002720| 20 66 6f 75 72 74 68 20 | 64 61 79 20 6f 66 20 74 | fourth |day of t|
|00002730| 68 65 20 6d 65 6e 73 74 | 72 75 61 6c 20 66 6c 6f |he menst|rual flo|
|00002740| 77 2e 0d 0a 20 20 20 20 | 20 42 6f 74 68 20 67 72 |w... | Both gr|
|00002750| 6f 75 70 73 20 68 61 64 | 20 73 69 6d 69 6c 61 72 |oups had| similar|
|00002760| 20 63 6f 6d 70 6c 61 69 | 6e 74 73 20 64 75 72 69 | complai|nts duri|
|00002770| 6e 67 20 74 68 65 20 70 | 72 65 6d 65 6e 73 74 72 |ng the p|remenstr|
|00002780| 75 61 6c 20 70 65 72 69 | 6f 64 2d 2d 70 61 69 6e |ual peri|od--pain|
|00002790| 0d 0a 70 65 72 63 65 70 | 74 69 6f 6e 20 61 6e 64 |..percep|tion and|
|000027a0| 20 6e 65 67 61 74 69 76 | 65 20 61 66 66 65 63 74 | negativ|e affect|
|000027b0| 2e 20 20 41 20 73 69 67 | 6e 69 66 69 63 61 6e 74 |. A sig|nificant|
|000027c0| 20 72 65 64 75 63 74 69 | 6f 6e 20 6f 66 20 70 61 | reducti|on of pa|
|000027d0| 69 6e 20 6f 63 63 75 72 | 72 65 64 20 6f 6e 6c 79 |in occur|red only|
|000027e0| 0d 0a 69 6e 20 74 68 65 | 20 64 72 75 67 2d 74 72 |..in the| drug-tr|
|000027f0| 65 61 74 65 64 20 67 72 | 6f 75 70 2e 20 20 50 61 |eated gr|oup. Pa|
|00002800| 69 6e 20 73 63 6f 72 65 | 73 20 64 65 63 72 65 61 |in score|s decrea|
|00002810| 73 65 64 20 66 72 6f 6d | 20 62 61 73 65 6c 69 6e |sed from| baselin|
|00002820| 65 20 76 61 6c 75 65 73 | 20 6f 6e 6c 79 0d 0a 64 |e values| only..d|
|00002830| 75 72 69 6e 67 20 6e 61 | 70 72 6f 78 65 6e 20 74 |uring na|proxen t|
|00002840| 72 65 61 74 6d 65 6e 74 | 2e 20 20 44 69 66 66 65 |reatment|. Diffe|
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|000035e0| 61 62 6c 65 20 6d 65 61 | 73 75 72 65 73 20 68 61 |able mea|sures ha|
|000035f0| 76 65 20 62 65 65 6e 20 | 61 74 74 65 6d 70 74 65 |ve been |attempte|
|00003600| 64 2e 0d 0a 24 55 6e 69 | 71 75 65 5f 49 44 7b 59 |d...$Uni|que_ID{Y|
|00003610| 52 42 30 32 38 30 34 7d | 0d 0a 24 54 69 74 6c 65 |RB02804}|..$Title|
|00003620| 7b 54 68 65 20 45 66 66 | 65 63 74 20 6f 66 20 48 |{The Eff|ect of H|
|00003630| 79 73 74 65 72 65 63 74 | 6f 6d 79 20 61 6e 64 20 |ysterect|omy and |
|00003640| 42 69 6c 61 74 65 72 61 | 6c 20 4f 6f 70 68 6f 72 |Bilatera|l Oophor|
|00003650| 65 63 74 6f 6d 79 20 69 | 6e 20 57 6f 6d 65 6e 20 |ectomy i|n Women |
|00003660| 57 69 74 68 0d 0a 53 65 | 76 65 72 65 20 50 72 65 |With..Se|vere Pre|
|00003670| 6d 65 6e 73 74 72 75 61 | 6c 20 53 79 6e 64 72 6f |menstrua|l Syndro|
|00003680| 6d 65 7d 0d 0a 24 41 75 | 74 68 6f 72 7b 0d 0a 43 |me}..$Au|thor{..C|
|00003690| 61 73 70 65 72 2c 20 52 | 46 0d 0a 48 65 61 72 6e |asper, R|F..Hearn|
|000036a0| 2c 20 4d 54 7d 0d 0a 24 | 41 66 66 69 6c 69 61 74 |, MT}..$|Affiliat|
|000036b0| 69 6f 6e 7b 55 6e 69 76 | 20 6f 66 20 57 65 73 74 |ion{Univ| of West|
|000036c0| 65 72 6e 20 4f 6e 74 61 | 72 69 6f 2c 20 4c 6f 6e |ern Onta|rio, Lon|
|000036d0| 64 6f 6e 2c 20 4f 6e 74 | 7d 0d 0a 24 4a 6f 75 72 |don, Ont|}..$Jour|
|000036e0| 6e 61 6c 7b 41 6d 20 4a | 20 4f 62 73 74 65 74 20 |nal{Am J| Obstet |
|000036f0| 47 79 6e 65 63 6f 6c 7d | 0d 0a 24 56 6f 6c 75 6d |Gynecol}|..$Volum|
|00003700| 65 7b 31 36 32 7d 0d 0a | 24 50 61 67 65 7b 31 30 |e{162}..|$Page{10|
|00003710| 35 2d 31 30 39 7d 0d 0a | 24 44 61 74 65 7b 31 39 |5-109}..|$Date{19|
|00003720| 39 30 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 39 31 |90}..$YB|Vol{1991|
|00003730| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 4f 62 | Year Bo|ok of Ob|
|00003740| 73 74 65 74 72 69 63 73 | 20 61 6e 64 20 47 79 6e |stetrics| and Gyn|
|00003750| 65 63 6f 6c 6f 67 79 7d | 0d 0a 24 43 68 61 70 74 |ecology}|..$Chapt|
|00003760| 65 72 7b 32 31 2d 39 7d | 0d 0a 24 59 42 45 64 69 |er{21-9}|..$YBEdi|
|00003770| 74 6f 72 7b 44 72 73 2e | 20 4d 69 73 68 65 6c 6c |tor{Drs.| Mishell|
|00003780| 2c 20 4b 69 72 73 63 68 | 62 61 75 6d 2c 20 61 6e |, Kirsch|baum, an|
|00003790| 64 20 4d 6f 72 72 6f 77 | 7d 0d 0a 24 54 61 62 6c |d Morrow|}..$Tabl|
|000037a0| 65 7b 54 61 62 6c 65 20 | 4f 6d 69 74 74 65 64 7d |e{Table |Omitted}|
|000037b0| 0d 0a 24 43 6f 6d 6d 65 | 6e 74 61 74 6f 72 7b 44 |..$Comme|ntator{D|
|000037c0| 2e 52 2e 20 4d 69 73 68 | 65 6c 6c 2c 20 4a 72 2e |.R. Mish|ell, Jr.|
|000037d0| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|000037e0| 69 67 68 74 20 28 43 29 | 20 59 65 61 72 20 42 6f |ight (C)| Year Bo|
|000037f0| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|00003800| 73 68 65 72 73 2c 20 49 | 6e 63 2e 20 31 39 39 31 |shers, I|nc. 1991|
|00003810| 0d 0a 0d 0a 31 39 39 31 | 20 59 65 61 72 20 42 6f |....1991| Year Bo|
|00003820| 6f 6b 20 6f 66 20 4f 62 | 73 74 65 74 72 69 63 73 |ok of Ob|stetrics|
|00003830| 20 61 6e 64 20 47 79 6e | 65 63 6f 6c 6f 67 79 0d | and Gyn|ecology.|
|00003840| 0a 0d 0a 47 79 6e 65 63 | 6f 6c 6f 67 79 0d 0a 0d |...Gynec|ology...|
|00003850| 0a 43 68 61 70 74 65 72 | 20 32 31 20 2d 2d 20 53 |.Chapter| 21 -- S|
|00003860| 65 78 75 61 6c 69 74 79 | 20 61 6e 64 20 50 72 65 |exuality| and Pre|
|00003870| 6d 65 6e 73 74 72 75 61 | 6c 20 53 79 6e 64 72 6f |menstrua|l Syndro|
|00003880| 6d 65 0d 0a 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |me....--|--------|
|00003890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000038a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000038b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000038c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000038d0| 2d 2d 2d 2d 0d 0a 54 68 | 65 20 45 66 66 65 63 74 |----..Th|e Effect|
|000038e0| 20 6f 66 20 48 79 73 74 | 65 72 65 63 74 6f 6d 79 | of Hyst|erectomy|
|000038f0| 20 61 6e 64 20 42 69 6c | 61 74 65 72 61 6c 20 4f | and Bil|ateral O|
|00003900| 6f 70 68 6f 72 65 63 74 | 6f 6d 79 20 69 6e 20 57 |ophorect|omy in W|
|00003910| 6f 6d 65 6e 20 57 69 74 | 68 20 53 65 76 65 72 65 |omen Wit|h Severe|
|00003920| 0d 0a 50 72 65 6d 65 6e | 73 74 72 75 61 6c 20 53 |..Premen|strual S|
|00003930| 79 6e 64 72 6f 6d 65 0d | 0a 0d 0a 43 61 73 70 65 |yndrome.|...Caspe|
|00003940| 72 20 52 46 3b 20 48 65 | 61 72 6e 20 4d 54 0d 0a |r RF; He|arn MT..|
|00003950| 28 55 6e 69 76 20 6f 66 | 20 57 65 73 74 65 72 6e |(Univ of| Western|
|00003960| 20 4f 6e 74 61 72 69 6f | 2c 20 4c 6f 6e 64 6f 6e | Ontario|, London|
|00003970| 2c 20 4f 6e 74 29 0d 0a | 41 6d 20 4a 20 4f 62 73 |, Ont)..|Am J Obs|
|00003980| 74 65 74 20 47 79 6e 65 | 63 6f 6c 20 31 36 32 3a |tet Gyne|col 162:|
|00003990| 31 30 35 2d 31 30 39 2c | 20 31 39 39 30 0d 0a 2d |105-109,| 1990..-|
|000039a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000039e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 0d |--------|-----...|
|000039f0| 0a 41 62 73 74 72 61 63 | 74 0d 0a 0d 0a 20 20 20 |.Abstrac|t.... |
|00003a00| 20 20 55 70 20 74 6f 20 | 33 30 25 20 6f 66 20 77 | Up to |30% of w|
|00003a10| 6f 6d 65 6e 20 6d 61 79 | 20 68 61 76 65 20 6d 6f |omen may| have mo|
|00003a20| 64 65 72 61 74 65 20 74 | 6f 20 73 65 76 65 72 65 |derate t|o severe|
|00003a30| 20 70 72 65 6d 65 6e 73 | 74 72 75 61 6c 20 73 79 | premens|trual sy|
|00003a40| 6e 64 72 6f 6d 65 0d 0a | 28 50 4d 53 29 2c 20 62 |ndrome..|(PMS), b|
|00003a50| 75 74 20 6f 6e 6c 79 20 | 35 25 20 68 61 76 65 20 |ut only |5% have |
|00003a60| 64 65 62 69 6c 69 74 61 | 74 69 6e 67 20 73 79 6d |debilita|ting sym|
|00003a70| 70 74 6f 6d 73 20 74 68 | 61 74 20 63 61 75 73 65 |ptoms th|at cause|
|00003a80| 20 6d 61 6a 6f 72 20 6c | 69 66 65 0d 0a 64 69 73 | major l|ife..dis|
|00003a90| 72 75 70 74 69 6f 6e 73 | 2e 20 20 54 68 65 20 65 |ruptions|. The e|
|00003aa0| 66 66 65 63 74 20 6f 66 | 20 73 75 72 67 69 63 61 |ffect of| surgica|
|00003ab0| 6c 6c 79 20 69 6e 64 75 | 63 65 64 20 6d 65 6e 6f |lly indu|ced meno|
|00003ac0| 70 61 75 73 65 20 61 6e | 64 20 73 75 62 73 65 71 |pause an|d subseq|
|00003ad0| 75 65 6e 74 0d 0a 63 6f | 6e 74 69 6e 75 6f 75 73 |uent..co|ntinuous|
|00003ae0| 20 65 73 74 72 6f 67 65 | 6e 20 72 65 70 6c 61 63 | estroge|n replac|
|00003af0| 65 6d 65 6e 74 20 69 6e | 20 77 6f 6d 65 6e 20 77 |ement in| women w|
|00003b00| 69 74 68 20 73 65 76 65 | 72 65 20 50 4d 53 20 77 |ith seve|re PMS w|
|00003b10| 61 73 20 69 6e 76 65 73 | 74 69 67 61 74 65 64 20 |as inves|tigated |
|00003b20| 69 6e 0d 0a 31 34 20 77 | 6f 6d 65 6e 20 61 67 65 |in..14 w|omen age|
|00003b30| 64 20 33 34 2d 34 36 20 | 79 65 61 72 73 2e 20 20 |d 34-46 |years. |
|00003b40| 54 77 65 6c 76 65 20 6f | 66 20 74 68 65 20 77 6f |Twelve o|f the wo|
|00003b50| 6d 65 6e 20 75 73 65 64 | 20 73 74 65 72 69 6c 69 |men used| sterili|
|00003b60| 7a 61 74 69 6f 6e 20 28 | 6f 66 0d 0a 74 68 65 6d |zation (|of..them|
|00003b70| 73 65 6c 76 65 73 20 6f | 72 20 74 68 65 69 72 20 |selves o|r their |
|00003b80| 70 61 72 74 6e 65 72 73 | 29 20 61 73 20 61 20 6d |partners|) as a m|
|00003b90| 65 61 6e 73 20 6f 66 20 | 63 6f 6e 74 72 61 63 65 |eans of |contrace|
|00003ba0| 70 74 69 6f 6e 2e 20 20 | 41 6c 6c 20 68 61 64 20 |ption. |All had |
|00003bb0| 63 6f 6d 70 6c 65 74 65 | 64 0d 0a 74 68 65 69 72 |complete|d..their|
|00003bc0| 20 66 61 6d 69 6c 69 65 | 73 20 61 6e 64 20 68 61 | familie|s and ha|
|00003bd0| 64 20 6e 6f 74 20 62 65 | 6e 65 66 69 74 65 64 20 |d not be|nefited |
|00003be0| 66 72 6f 6d 20 70 72 65 | 76 69 6f 75 73 20 6d 65 |from pre|vious me|
|00003bf0| 64 69 63 61 6c 20 74 68 | 65 72 61 70 79 2e 20 20 |dical th|erapy. |
|00003c00| 41 0d 0a 70 72 6f 73 70 | 65 63 74 69 76 65 20 63 |A..prosp|ective c|
|00003c10| 68 61 72 74 69 6e 67 20 | 61 6e 64 20 70 73 79 63 |harting |and psyc|
|00003c20| 68 6f 6c 6f 67 69 63 61 | 6c 20 61 73 73 65 73 73 |hologica|l assess|
|00003c30| 6d 65 6e 74 20 77 65 72 | 65 20 75 73 65 64 20 74 |ment wer|e used t|
|00003c40| 6f 20 65 76 61 6c 75 61 | 74 65 20 74 68 65 0d 0a |o evalua|te the..|
|00003c50| 73 65 76 65 72 69 74 79 | 20 6f 66 20 50 4d 53 2e |severity| of PMS.|
|00003c60| 0d 0a 20 20 20 20 20 41 | 6c 6c 20 77 6f 6d 65 6e |.. A|ll women|
|00003c70| 20 68 61 64 20 63 79 63 | 6c 69 63 20 73 79 6d 70 | had cyc|lic symp|
|00003c80| 74 6f 6d 73 2e 20 20 54 | 68 65 69 72 20 70 73 79 |toms. T|heir psy|
|00003c90| 63 68 6f 6c 6f 67 69 63 | 61 6c 20 73 63 6f 72 65 |chologic|al score|
|00003ca0| 73 20 69 6e 64 69 63 61 | 74 65 64 0d 0a 6d 61 6a |s indica|ted..maj|
|00003cb0| 6f 72 20 6c 69 66 65 20 | 64 69 73 72 75 70 74 69 |or life |disrupti|
|00003cc0| 6f 6e 73 2e 20 20 42 79 | 20 36 20 6d 6f 6e 74 68 |ons. By| 6 month|
|00003cd0| 73 20 61 66 74 65 72 20 | 73 75 72 67 65 72 79 20 |s after |surgery |
|00003ce0| 74 68 65 20 63 79 63 6c | 69 63 20 70 61 74 74 65 |the cycl|ic patte|
|00003cf0| 72 6e 20 6f 66 20 50 4d | 53 0d 0a 73 79 6d 70 74 |rn of PM|S..sympt|
|00003d00| 6f 6d 73 20 68 61 64 20 | 63 6f 6d 70 6c 65 74 65 |oms had |complete|
|00003d10| 6c 79 20 64 69 73 61 70 | 70 65 61 72 65 64 20 28 |ly disap|peared (|
|00003d20| 46 69 67 20 32 31 2d 34 | 29 2e 20 20 53 79 6d 70 |Fig 21-4|). Symp|
|00003d30| 74 6f 6d 20 63 68 61 72 | 74 69 6e 67 20 79 69 65 |tom char|ting yie|
|00003d40| 6c 64 65 64 0d 0a 73 63 | 6f 72 65 73 20 65 71 75 |lded..sc|ores equ|
|00003d50| 69 76 61 6c 65 6e 74 20 | 74 6f 20 74 68 6f 73 65 |ivalent |to those|
|00003d60| 20 6f 66 20 74 68 65 20 | 6e 6f 72 6d 61 6c 20 70 | of the |normal p|
|00003d70| 6f 70 75 6c 61 74 69 6f | 6e 2e 20 20 50 73 79 63 |opulatio|n. Psyc|
|00003d80| 68 6f 6c 6f 67 69 63 61 | 6c 20 6d 65 61 73 75 72 |hologica|l measur|
|00003d90| 65 73 20 36 0d 0a 6d 6f | 6e 74 68 73 20 61 66 74 |es 6..mo|nths aft|
|00003da0| 65 72 20 73 75 72 67 65 | 72 79 20 73 68 6f 77 65 |er surge|ry showe|
|00003db0| 64 20 64 72 61 6d 61 74 | 69 63 20 69 6d 70 72 6f |d dramat|ic impro|
|00003dc0| 76 65 6d 65 6e 74 73 20 | 69 6e 20 6d 6f 6f 64 2c |vements |in mood,|
|00003dd0| 20 67 65 6e 65 72 61 6c | 20 61 66 66 65 63 74 2c | general| affect,|
|00003de0| 0d 0a 77 65 6c 6c 2d 62 | 65 69 6e 67 2c 20 6c 69 |..well-b|eing, li|
|00003df0| 66 65 20 73 61 74 69 73 | 66 61 63 74 69 6f 6e 2c |fe satis|faction,|
|00003e00| 20 61 6e 64 20 6f 76 65 | 72 61 6c 6c 20 71 75 61 | and ove|rall qua|
|00003e10| 6c 69 74 79 20 6f 66 20 | 6c 69 66 65 2e 0d 0a 20 |lity of |life... |
|00003e20| 20 20 20 20 53 75 72 67 | 69 63 61 6c 20 74 68 65 | Surg|ical the|
|00003e30| 72 61 70 79 20 69 6e 76 | 6f 6c 76 69 6e 67 20 6f |rapy inv|olving o|
|00003e40| 6f 70 68 6f 72 65 63 74 | 6f 6d 79 2c 20 68 79 73 |ophorect|omy, hys|
|00003e50| 74 65 72 65 63 74 6f 6d | 79 2c 20 61 6e 64 20 63 |terectom|y, and c|
|00003e60| 6f 6e 74 69 6e 75 6f 75 | 73 0d 0a 65 73 74 72 6f |ontinuou|s..estro|
|00003e70| 67 65 6e 20 72 65 70 6c | 61 63 65 6d 65 6e 74 20 |gen repl|acement |
|00003e80| 66 6f 72 20 73 65 76 65 | 72 65 20 50 4d 53 20 69 |for seve|re PMS i|
|00003e90| 73 20 77 61 72 72 61 6e | 74 65 64 20 69 6e 20 61 |s warran|ted in a|
|00003ea0| 20 73 6d 61 6c 6c 20 70 | 65 72 63 65 6e 74 61 67 | small p|ercentag|
|00003eb0| 65 20 6f 66 0d 0a 77 6f | 6d 65 6e 20 77 68 6f 20 |e of..wo|men who |
|00003ec0| 65 78 70 65 72 69 65 6e | 63 65 20 64 65 62 69 6c |experien|ce debil|
|00003ed0| 69 74 61 74 69 6e 67 20 | 73 79 6d 70 74 6f 6d 73 |itating |symptoms|
|00003ee0| 2e 20 20 54 68 65 20 64 | 69 61 67 6e 6f 73 69 73 |. The d|iagnosis|
|00003ef0| 20 6f 66 20 73 65 76 65 | 72 65 20 50 4d 53 0d 0a | of seve|re PMS..|
|00003f00| 73 68 6f 75 6c 64 20 62 | 65 20 65 73 74 61 62 6c |should b|e establ|
|00003f10| 69 73 68 65 64 20 62 79 | 20 70 72 6f 73 70 65 63 |ished by| prospec|
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|00003f30| 53 75 72 67 65 72 79 20 | 73 68 6f 75 6c 64 20 62 |Surgery |should b|
|00003f40| 65 20 63 6f 6e 73 69 64 | 65 72 65 64 0d 0a 6f 6e |e consid|ered..on|
|00003f50| 6c 79 20 61 66 74 65 72 | 20 6f 74 68 65 72 20 66 |ly after| other f|
|00003f60| 6f 72 6d 73 20 6f 66 20 | 74 72 65 61 74 6d 65 6e |orms of |treatmen|
|00003f70| 74 20 68 61 76 65 20 66 | 61 69 6c 65 64 2e 0d 0a |t have f|ailed...|
|00003f80| 0d 0a 50 6f 73 74 2d 43 | 6f 6d 6d 65 6e 74 0d 0a |..Post-C|omment..|
|00003f90| 0d 0a 20 20 20 20 20 54 | 68 65 73 65 20 32 20 73 |.. T|hese 2 s|
|00003fa0| 74 75 64 69 65 73 20 66 | 72 6f 6d 20 43 61 6e 61 |tudies f|rom Cana|
|00003fb0| 64 61 20 28 41 62 73 74 | 72 61 63 74 73 20 32 31 |da (Abst|racts 21|
|00003fc0| 2d 38 20 61 6e 64 20 32 | 31 2d 39 29 20 69 6e 64 |-8 and 2|1-9) ind|
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|00003fe0| 69 6e 67 20 72 65 6c 69 | 65 66 20 66 72 6f 6d 20 |ing reli|ef from |
|00003ff0| 73 65 76 65 72 65 6c 79 | 20 64 65 62 69 6c 69 74 |severely| debilit|
|00004000| 61 74 69 6e 67 20 70 72 | 65 6d 65 6e 73 74 72 75 |ating pr|emenstru|
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|00004020| 62 65 0d 0a 61 63 68 69 | 65 76 65 64 20 62 79 20 |be..achi|eved by |
|00004030| 73 75 72 67 69 63 61 6c | 6c 79 20 72 65 6d 6f 76 |surgical|ly remov|
|00004040| 69 6e 67 20 74 68 65 20 | 6f 76 61 72 69 65 73 2e |ing the |ovaries.|
|00004050| 20 20 48 79 73 74 65 72 | 65 63 74 6f 6d 79 20 77 | Hyster|ectomy w|
|00004060| 61 73 20 61 6c 73 6f 20 | 70 65 72 66 6f 72 6d 65 |as also |performe|
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|000040e0| 65 74 69 6d 65 73 2c 20 | 74 68 65 20 63 79 63 6c |etimes, |the cycl|
|000040f0| 69 63 20 61 64 64 69 74 | 69 6f 6e 20 6f 66 20 65 |ic addit|ion of e|
|00004100| 78 6f 67 65 6e 6f 75 73 | 0d 0a 70 72 6f 67 65 73 |xogenous|..proges|
|00004110| 74 69 6e 73 20 69 6e 20 | 70 6f 73 74 6d 65 6e 6f |tins in |postmeno|
|00004120| 70 61 75 73 61 6c 20 65 | 73 74 72 6f 67 65 6e 20 |pausal e|strogen |
|00004130| 72 65 70 6c 61 63 65 6d | 65 6e 74 20 72 65 67 69 |replacem|ent regi|
|00004140| 6d 65 6e 73 20 72 65 73 | 75 6c 74 73 20 69 6e 20 |mens res|ults in |
|00004150| 61 0d 0a 72 65 63 75 72 | 72 65 6e 63 65 20 6f 66 |a..recur|rence of|
|00004160| 20 73 6f 6d 65 20 6f 66 | 20 74 68 65 20 73 79 6d | some of| the sym|
|00004170| 70 74 6f 6d 73 20 61 73 | 73 6f 63 69 61 74 65 64 |ptoms as|sociated|
|00004180| 20 77 69 74 68 20 50 4d | 53 2e 20 20 4f 62 76 69 | with PM|S. Obvi|
|00004190| 6f 75 73 6c 79 2c 20 74 | 68 69 73 20 74 79 70 65 |ously, t|his type|
|000041a0| 0d 0a 6f 66 20 74 68 65 | 72 61 70 79 20 73 68 6f |..of the|rapy sho|
|000041b0| 75 6c 64 20 62 65 20 74 | 72 69 65 64 20 6f 6e 6c |uld be t|ried onl|
|000041c0| 79 20 61 66 74 65 72 20 | 63 68 69 6c 64 62 65 61 |y after |childbea|
|000041d0| 72 69 6e 67 20 69 73 20 | 63 6f 6d 70 6c 65 74 65 |ring is |complete|
|000041e0| 20 61 6e 64 20 6f 74 68 | 65 72 0d 0a 74 68 65 72 | and oth|er..ther|
|000041f0| 61 70 65 75 74 69 63 20 | 6d 6f 64 61 6c 69 74 69 |apeutic |modaliti|
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|00004210| 6d 62 69 6e 65 64 20 6c | 6f 77 2d 64 6f 73 65 20 |mbined l|ow-dose |
|00004220| 6f 72 61 6c 20 63 6f 6e | 74 72 61 63 65 70 74 69 |oral con|tracepti|
|00004230| 76 65 20 75 73 65 2c 0d | 0a 68 61 76 65 20 6e 6f |ve use,.|.have no|
|00004240| 74 20 61 6c 6c 65 76 69 | 61 74 65 64 20 74 68 65 |t allevi|ated the|
|00004250| 20 73 65 76 65 72 65 20 | 73 79 6d 70 74 6f 6d 73 | severe |symptoms|
|00004260| 2e 20 20 41 20 74 72 69 | 61 6c 20 6f 66 20 6d 65 |. A tri|al of me|
|00004270| 64 69 63 61 6c 20 6f 76 | 61 72 69 61 6e 0d 0a 73 |dical ov|arian..s|
|00004280| 75 70 70 72 65 73 73 69 | 6f 6e 20 77 69 74 68 20 |uppressi|on with |
|00004290| 64 61 6e 61 7a 6f 6c 20 | 6f 72 20 61 20 67 6f 6e |danazol |or a gon|
|000042a0| 61 64 6f 74 72 6f 70 69 | 6e 2d 72 65 6c 65 61 73 |adotropi|n-releas|
|000042b0| 69 6e 67 20 68 6f 72 6d | 6f 6e 65 20 61 6e 61 6c |ing horm|one anal|
|000042c0| 6f 67 75 65 20 73 68 6f | 75 6c 64 0d 0a 62 65 20 |ogue sho|uld..be |
|000042d0| 67 69 76 65 6e 20 66 6f | 72 20 61 20 66 65 77 20 |given fo|r a few |
|000042e0| 6d 6f 6e 74 68 73 20 74 | 6f 20 73 65 65 20 69 66 |months t|o see if|
|000042f0| 20 74 68 65 20 73 79 6d | 70 74 6f 6d 73 20 61 72 | the sym|ptoms ar|
|00004300| 65 20 72 65 6c 69 65 76 | 65 64 20 62 65 66 6f 72 |e reliev|ed befor|
|00004310| 65 0d 0a 70 65 72 66 6f | 72 6d 69 6e 67 20 6f 76 |e..perfo|rming ov|
|00004320| 61 72 69 65 63 74 6f 6d | 79 2e 2d 2d 44 2e 52 2e |ariectom|y.--D.R.|
|00004330| 20 4d 69 73 68 65 6c 6c | 2c 20 4a 72 2e 2c 20 4d | Mishell|, Jr., M|
|00004340| 2e 44 2e 0d 0a 24 55 6e | 69 71 75 65 5f 49 44 7b |.D...$Un|ique_ID{|
|00004350| 59 52 42 30 32 38 30 35 | 7d 0d 0a 24 54 69 74 6c |YRB02805|}..$Titl|
|00004360| 65 7b 4e 6f 6e 2d 43 79 | 63 6c 69 63 61 6c 20 4d |e{Non-Cy|clical M|
|00004370| 61 73 74 61 6c 67 69 61 | 3a 20 20 41 6e 20 49 6d |astalgia|: An Im|
|00004380| 70 72 6f 76 65 64 20 43 | 6c 61 73 73 69 66 69 63 |proved C|lassific|
|00004390| 61 74 69 6f 6e 20 61 6e | 64 20 54 72 65 61 74 6d |ation an|d Treatm|
|000043a0| 65 6e 74 7d 0d 0a 24 41 | 75 74 68 6f 72 7b 0d 0a |ent}..$A|uthor{..|
|000043b0| 4d 61 64 64 6f 78 2c 20 | 50 52 0d 0a 48 61 72 72 |Maddox, |PR..Harr|
|000043c0| 69 73 6f 6e 2c 20 42 4a | 0d 0a 4d 61 6e 73 65 6c |ison, BJ|..Mansel|
|000043d0| 2c 20 52 45 0d 0a 48 75 | 67 68 65 73 2c 20 4c 45 |, RE..Hu|ghes, LE|
|000043e0| 7d 0d 0a 24 41 66 66 69 | 6c 69 61 74 69 6f 6e 7b |}..$Affi|liation{|
|000043f0| 55 6e 69 76 20 6f 66 20 | 57 61 6c 65 73 2c 20 43 |Univ of |Wales, C|
|00004400| 61 72 64 69 66 66 7d 0d | 0a 24 4a 6f 75 72 6e 61 |ardiff}.|.$Journa|
|00004410| 6c 7b 42 72 20 4a 20 53 | 75 72 67 7d 0d 0a 24 56 |l{Br J S|urg}..$V|
|00004420| 6f 6c 75 6d 65 7b 37 36 | 7d 0d 0a 24 50 61 67 65 |olume{76|}..$Page|
|00004430| 7b 39 30 31 2d 39 30 34 | 7d 0d 0a 24 44 61 74 65 |{901-904|}..$Date|
|00004440| 7b 31 39 38 39 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 |{1989}..|$YBVol{1|
|00004450| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|00004460| 20 4f 62 73 74 65 74 72 | 69 63 73 20 61 6e 64 20 | Obstetr|ics and |
|00004470| 47 79 6e 65 63 6f 6c 6f | 67 79 7d 0d 0a 24 43 68 |Gynecolo|gy}..$Ch|
|00004480| 61 70 74 65 72 7b 32 32 | 2d 31 7d 0d 0a 24 59 42 |apter{22|-1}..$YB|
|00004490| 45 64 69 74 6f 72 7b 44 | 72 73 2e 20 4d 69 73 68 |Editor{D|rs. Mish|
|000044a0| 65 6c 6c 2c 20 4b 69 72 | 73 63 68 62 61 75 6d 2c |ell, Kir|schbaum,|
|000044b0| 20 61 6e 64 20 4d 6f 72 | 72 6f 77 7d 0d 0a 24 54 | and Mor|row}..$T|
|000044c0| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|000044d0| 61 74 6f 72 7b 57 2e 48 | 2e 20 48 69 6e 64 6c 65 |ator{W.H|. Hindle|
|000044e0| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|000044f0| 69 67 68 74 20 28 43 29 | 20 59 65 61 72 20 42 6f |ight (C)| Year Bo|
|00004500| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|00004510| 73 68 65 72 73 2c 20 49 | 6e 63 2e 20 31 39 39 31 |shers, I|nc. 1991|
|00004520| 0d 0a 0d 0a 31 39 39 31 | 20 59 65 61 72 20 42 6f |....1991| Year Bo|
|00004530| 6f 6b 20 6f 66 20 4f 62 | 73 74 65 74 72 69 63 73 |ok of Ob|stetrics|
|00004540| 20 61 6e 64 20 47 79 6e | 65 63 6f 6c 6f 67 79 0d | and Gyn|ecology.|
|00004550| 0a 0d 0a 47 79 6e 65 63 | 6f 6c 6f 67 79 0d 0a 0d |...Gynec|ology...|
|00004560| 0a 43 68 61 70 74 65 72 | 20 32 32 20 2d 2d 20 42 |.Chapter| 22 -- B|
|00004570| 72 65 61 73 74 20 44 69 | 73 65 61 73 65 73 0d 0a |reast Di|seases..|
|00004580| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00004590| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000045a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000045b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000045c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000045d0| 0d 0a 4e 6f 6e 2d 43 79 | 63 6c 69 63 61 6c 20 4d |..Non-Cy|clical M|
|000045e0| 61 73 74 61 6c 67 69 61 | 3a 20 20 41 6e 20 49 6d |astalgia|: An Im|
|000045f0| 70 72 6f 76 65 64 20 43 | 6c 61 73 73 69 66 69 63 |proved C|lassific|
|00004600| 61 74 69 6f 6e 20 61 6e | 64 20 54 72 65 61 74 6d |ation an|d Treatm|
|00004610| 65 6e 74 0d 0a 0d 0a 4d | 61 64 64 6f 78 20 50 52 |ent....M|addox PR|
|00004620| 3b 20 48 61 72 72 69 73 | 6f 6e 20 42 4a 3b 20 4d |; Harris|on BJ; M|
|00004630| 61 6e 73 65 6c 20 52 45 | 3b 20 48 75 67 68 65 73 |ansel RE|; Hughes|
|00004640| 20 4c 45 0d 0a 28 55 6e | 69 76 20 6f 66 20 57 61 | LE..(Un|iv of Wa|
|00004650| 6c 65 73 2c 20 43 61 72 | 64 69 66 66 29 0d 0a 42 |les, Car|diff)..B|
|00004660| 72 20 4a 20 53 75 72 67 | 20 37 36 3a 39 30 31 2d |r J Surg| 76:901-|
|00004670| 39 30 34 2c 20 31 39 38 | 39 0d 0a 2d 2d 2d 2d 2d |904, 198|9..-----|
|00004680| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004690| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000046a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000046b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000046c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 0d 0a 41 62 73 |--------|-....Abs|
|000046d0| 74 72 61 63 74 0d 0a 0d | 0a 20 20 20 20 20 49 6e |tract...|. In|
|000046e0| 20 74 68 65 20 70 61 73 | 74 2c 20 62 72 65 61 73 | the pas|t, breas|
|000046f0| 74 20 70 61 69 6e 20 6f | 66 74 65 6e 20 68 61 73 |t pain o|ften has|
|00004700| 20 62 65 65 6e 20 72 65 | 67 61 72 64 65 64 20 61 | been re|garded a|
|00004710| 73 20 61 20 74 72 69 76 | 69 61 6c 20 63 6f 6d 70 |s a triv|ial comp|
|00004720| 6c 61 69 6e 74 0d 0a 6f | 66 20 70 73 79 63 68 6f |laint..o|f psycho|
|00004730| 6c 6f 67 69 63 61 6c 20 | 6f 72 69 67 69 6e 2e 20 |logical |origin. |
|00004740| 20 4d 6f 72 65 20 72 65 | 63 65 6e 74 6c 79 2c 20 | More re|cently, |
|00004750| 33 20 64 69 66 66 65 72 | 65 6e 74 20 70 61 74 74 |3 differ|ent patt|
|00004760| 65 72 6e 73 20 6f 66 20 | 62 72 65 61 73 74 20 70 |erns of |breast p|
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|000047a0| 2c 20 61 6e 64 20 54 69 | 65 74 7a 65 27 73 20 73 |, and Ti|etze's s|
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|00005e20| 5f 49 44 7b 59 52 42 30 | 32 38 30 37 7d 0d 0a 24 |_ID{YRB0|2807}..$|
|00005e30| 54 69 74 6c 65 7b 56 69 | 74 61 6d 69 6e 20 45 20 |Title{Vi|tamin E |
|00005e40| 61 6e 64 20 42 65 6e 69 | 67 6e 20 42 72 65 61 73 |and Beni|gn Breas|
|00005e50| 74 20 44 69 73 65 61 73 | 65 7d 0d 0a 24 41 75 74 |t Diseas|e}..$Aut|
|00005e60| 68 6f 72 7b 0d 0a 4d 65 | 79 65 72 2c 20 45 43 0d |hor{..Me|yer, EC.|
|00005e70| 0a 53 6f 6d 6d 65 72 73 | 2c 20 44 65 4b 0d 0a 52 |.Sommers|, DeK..R|
|00005e80| 65 69 74 7a 2c 20 43 4a | 0d 0a 4d 65 6e 74 69 73 |eitz, CJ|..Mentis|
|00005e90| 2c 20 48 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 |, H}..$A|ffiliati|
|00005ea0| 6f 6e 7b 55 6e 69 76 20 | 6f 66 20 50 72 65 74 6f |on{Univ |of Preto|
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|00005ec0| 61 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 53 75 72 |a}..$Jou|rnal{Sur|
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|00005ef0| 35 31 7d 0d 0a 24 44 61 | 74 65 7b 31 39 39 30 7d |51}..$Da|te{1990}|
|00005f00| 0d 0a 24 59 42 56 6f 6c | 7b 31 39 39 31 20 59 65 |..$YBVol|{1991 Ye|
|00005f10| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 4f 62 73 74 65 |ar Book |of Obste|
|00005f20| 74 72 69 63 73 20 61 6e | 64 20 47 79 6e 65 63 6f |trics an|d Gyneco|
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|00005f40| 32 32 2d 33 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |22-3}..$|YBEditor|
|00005f50| 7b 44 72 73 2e 20 4d 69 | 73 68 65 6c 6c 2c 20 4b |{Drs. Mi|shell, K|
|00005f60| 69 72 73 63 68 62 61 75 | 6d 2c 20 61 6e 64 20 4d |irschbau|m, and M|
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|00005f80| 0d 0a 24 43 6f 6d 6d 65 | 6e 74 61 74 6f 72 7b 7d |..$Comme|ntator{}|
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|00005fa0| 29 20 59 65 61 72 20 42 | 6f 6f 6b 20 4d 65 64 69 |) Year B|ook Medi|
|00005fb0| 63 61 6c 20 50 75 62 6c | 69 73 68 65 72 73 2c 20 |cal Publ|ishers, |
|00005fc0| 49 6e 63 2e 20 31 39 39 | 31 0d 0a 0d 0a 31 39 39 |Inc. 199|1....199|
|00005fd0| 31 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 4f |1 Year B|ook of O|
|00005fe0| 62 73 74 65 74 72 69 63 | 73 20 61 6e 64 20 47 79 |bstetric|s and Gy|
|00005ff0| 6e 65 63 6f 6c 6f 67 79 | 0d 0a 0d 0a 47 79 6e 65 |necology|....Gyne|
|00006000| 63 6f 6c 6f 67 79 0d 0a | 0d 0a 43 68 61 70 74 65 |cology..|..Chapte|
|00006010| 72 20 32 32 20 2d 2d 20 | 42 72 65 61 73 74 20 44 |r 22 -- |Breast D|
|00006020| 69 73 65 61 73 65 73 0d | 0a 0d 0a 2d 2d 2d 2d 2d |iseases.|...-----|
|00006030| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006040| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006050| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006060| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006070| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 56 69 74 61 6d |--------|-..Vitam|
|00006080| 69 6e 20 45 20 61 6e 64 | 20 42 65 6e 69 67 6e 20 |in E and| Benign |
|00006090| 42 72 65 61 73 74 20 44 | 69 73 65 61 73 65 0d 0a |Breast D|isease..|
|000060a0| 0d 0a 4d 65 79 65 72 20 | 45 43 3b 20 53 6f 6d 6d |..Meyer |EC; Somm|
|000060b0| 65 72 73 20 44 65 4b 3b | 20 52 65 69 74 7a 20 43 |ers DeK;| Reitz C|
|000060c0| 4a 3b 20 4d 65 6e 74 69 | 73 20 48 0d 0a 28 55 6e |J; Menti|s H..(Un|
|000060d0| 69 76 20 6f 66 20 50 72 | 65 74 6f 72 69 61 2c 20 |iv of Pr|etoria, |
|000060e0| 53 6f 75 74 68 20 41 66 | 72 69 63 61 29 0d 0a 53 |South Af|rica)..S|
|000060f0| 75 72 67 65 72 79 20 31 | 30 37 3a 35 34 39 2d 35 |urgery 1|07:549-5|
|00006100| 35 31 2c 20 31 39 39 30 | 0d 0a 2d 2d 2d 2d 2d 2d |51, 1990|..------|
|00006110| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006120| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006130| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006140| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006150| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 41 62 73 74 |--------|....Abst|
|00006160| 72 61 63 74 0d 0a 0d 0a | 20 20 20 20 20 45 61 72 |ract....| Ear|
|00006170| 6c 69 65 72 20 72 65 70 | 6f 72 74 73 20 68 61 76 |lier rep|orts hav|
|00006180| 65 20 69 6e 64 69 63 61 | 74 65 64 20 74 68 61 74 |e indica|ted that|
|00006190| 20 76 69 74 61 6d 69 6e | 20 45 20 28 61 6c 70 68 | vitamin| E (alph|
|000061a0| 61 2d 74 6f 63 6f 70 68 | 65 72 6f 6c 29 20 69 73 |a-tocoph|erol) is|
|000061b0| 0d 0a 65 66 66 65 63 74 | 69 76 65 20 69 6e 20 74 |..effect|ive in t|
|000061c0| 68 65 20 74 72 65 61 74 | 6d 65 6e 74 20 6f 66 20 |he treat|ment of |
|000061d0| 62 65 6e 69 67 6e 20 62 | 72 65 61 73 74 20 64 69 |benign b|reast di|
|000061e0| 73 65 61 73 65 20 28 66 | 69 62 72 6f 63 79 73 74 |sease (f|ibrocyst|
|000061f0| 69 63 20 64 69 73 65 61 | 73 65 29 2c 20 62 75 74 |ic disea|se), but|
|00006200| 0d 0a 74 68 65 73 65 20 | 73 74 75 64 69 65 73 20 |..these |studies |
|00006210| 77 65 72 65 20 6f 66 74 | 65 6e 20 73 6d 61 6c 6c |were oft|en small|
|00006220| 20 61 6e 64 20 69 6c 6c | 20 64 65 73 69 67 6e 65 | and ill| designe|
|00006230| 64 2e 20 20 55 73 69 6e | 67 20 6d 61 6d 6d 6f 67 |d. Usin|g mammog|
|00006240| 72 61 70 68 79 20 61 73 | 20 74 68 65 0d 0a 6f 62 |raphy as| the..ob|
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|00006270| 20 74 68 65 20 65 66 66 | 69 63 61 63 79 20 6f 66 | the eff|icacy of|
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|00006340| 72 65 61 73 74 20 64 69 | 73 65 61 73 65 2c 20 72 |reast di|sease, r|
|00006350| 65 63 65 69 76 65 64 20 | 65 69 74 68 65 72 20 61 |eceived |either a|
|00006360| 6c 70 68 61 2d 74 6f 63 | 6f 70 68 65 72 6f 6c 20 |lpha-toc|opherol |
|00006370| 61 63 65 74 61 74 65 2c | 20 36 30 30 20 6d 67 2c |acetate,| 600 mg,|
|00006380| 20 6f 72 0d 0a 70 6c 61 | 63 65 62 6f 20 69 6e 20 | or..pla|cebo in |
|00006390| 33 2d 6d 6f 6e 74 68 20 | 74 72 65 61 74 6d 65 6e |3-month |treatmen|
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|000063b0| 41 6c 74 68 6f 75 67 68 | 20 73 75 62 6a 65 63 74 |Although| subject|
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+--------+-------------------------+-------------------------+--------+--------+
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